Synthesis and bioactivity of 2-arylimino-4-thiazolidones / 药学学报
Acta Pharmaceutica Sinica
; (12): 825-829, 2006.
Article
in Zh
| WPRIM
| ID: wpr-294931
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To synthesize a series of 2-arylimino-4-thiazolidone derivatives and 2-imidazolino [2,3-b]-4-thiazolidone in order to get some novel potent compounds with nitric oxide synthases (NOS) inhibitory activity.</p><p><b>METHODS</b>The target compounds were prepared by reaction of N-chloroacetyl-1,2,3,4-tetrahydroisoquinoline or N-chloroacetylphthalimide with substituted thioureas, their NOS inhibitory activity were measured.</p><p><b>RESULTS AND CONCLUSION</b>The 15 new compounds were synthesized and most of the reaction yields were over 65%. The structures of new compounds were identified by IR, 1H NMR, MS and elemental analyses. Bioassay indicated that, most of 15 new compounds synthesized had confirmed bioactivities inhibition against NOS.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
/
Structure-Activity Relationship
/
Thiazoles
/
Thiourea
/
Molecular Structure
/
Chemistry
/
Nitric Oxide Synthase
/
Metabolism
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2006
Document type:
Article